Gpro web interface user manual

Finally, for questions about how to register, please contact the Quality Net Help Desk at TTY: , or by email: qnetsupport hcqis. Posted on May 13, by David Twiddy. FPM Home. Past Issues. CME Quiz. Getting Paid. Quick Tips. ATX Form Factor: Please realize that there is a certain risk involved with overclocking, including adjusting the setting in the BIOS, applying Untied Overclocking Technology, or using the thirdparty overclocking tools. Overclocking may affect your system stability, or even cause damage to the components and devices of your system.

It should be done at your own risk and expense. We are not responsible for possible damage caused by overclocking. Just launch this tool and save the new BIOS file to your USB flash drive, floppy disk or hard drive, then you can update your BIOS only in a few clicks without preparing an additional floppy diskette or other complicated flash utility.

It helps you to save your overclocking record under the operating system and simplifies the complicated recording process of overclocking settings. Your friends then can load the OC profile to their own system to get the same OC settings as yours! Please be noticed that the OC profile can only be shared and worked on the same motherboard.

Although this motherboard offers stepless control, it is not recommended to perform over-clocking. While CPU overheat is detected, the system will automatically shutdown. Before you resume the system, please check if the CPU fan on the motherboard functions properly and unplug the power cord, then plug it back again. To improve heat dissipation, remember to spray thermal grease between the CPU and the heatsink when you install the PC system. EuP, stands for Energy Using Product, was a provision regulated by European Union to define the power consumption for the completed system.

According to EuP, the total AC power of the completed system shall be under 1. For EuP ready power supply selection, we recommend you checking with the power supply manufacturer for more details.

This is an ATX form factor Before you install the motherboard, study the configuration of your chassis to ensure that the motherboard fits into it. Take note of the following precautions before you install motherboard components or change any motherboard settings.

Before you install or remove any component, ensure that the power is switched off or the power cord is detached from the power supply.

Unplug the power cord from the wall socket before touching any component. To avoid damaging the motherboard components due to static electricity, NEVER place your motherboard directly on the carpet or the like. Also remember to use a grounded wrist strap or touch a safety grounded object before you handle components. Hold components by the edges and do not touch the ICs.

Whenever you uninstall any component, place it on a grounded antistatic pad or in the bag that comes with the component. When placing screws into the screw holes to secure the motherboard to the chassis, please do not over-tighten the screws!

Doing so may damage the motherboard. Step 1. Unlock the socket by lifting the lever up to a 90 o angle. Step 2. Position the CPU directly above the socket such that the CPU corner with the golden triangle matches the socket corner with a small triangle. The CPU fits only in one correct orientation. Step 4. The lever clicks on the side tab to indicate that it is locked.

After you install the CPU into this motherboard, it is necessary to install a larger heatsink and cooling fan to dissipate heat. You also need to spray thermal grease between the CPU and the heatsink to improve heat dissipation. Make sure that the CPU and the heatsink are securely fastened and in good contact with each other.

For proper installation, please kindly refer to the instruction manuals of the CPU fan and the heatsink. For dual channel configuration, you always need to install identical the same brand, speed, size and chiptype DDR3 DIMM pair in the slots of the same color. If you want to install two memory modules, for optimal compatibility and reliability, it is recommended to install them in the slots of the same color.

Please make sure to disconnect power supply before adding or removing DIMMs or the system components. The DIMM only fits in one correct orientation. Step 3. Before installing the expansion card, please make sure that the power supply is switched off or the power cord is unplugged. Please read the documentation of the expansion card and make necessary hardware settings for the card before you start the installation.

Remove the system unit cover if your motherboard is already installed in a chassis. Remove the bracket facing the slot that you intend to use.

Keep the screws for later use. Align the card connector with the slot and press firmly until the card is completely seated on the slot. Step 5. Fasten the card to the chassis with screws. Step 6. Replace the system cover.

This motherboard supports dual monitor feature. This motherboard supports surround display upgrade. Please refer to page 14 for proper expansion card installation procedures for details. Boot your system. Please make sure that the value you select is less than the total capability of the system memory. If you have installed the drivers already, there is no need to install them again.

Set up a multi-monitor display. When you use multiple monitors with your card, one monitor will always be Primary, and all additional monitors will be designated as Secondary. Select the display icon identified by the number 2. Repeat steps C through E for the diaplay icon identified by the number one, two, three and four. Repeat steps A through C for the display icon identified by the number three and four. Use Surround Display.

Click and drag the display icons to positions representing the physical setup of your monitors that you would like to use. The placement of display icons determines how you move items from one monitor to another. HDCP function is supported on this motherboard. Therefore, you can enjoy the superior display quality with high-definition HDCP encryption contents. The Gaggle-based integrated solutions are powerful but particularly the divergent interfaces users are confronted with, might be challenging for nonspecialists.

Finally, several commercial solutions are available, e. However, the high expenses associated with these programs and the intransparent nature of commercial software solutions might pose a significant obstacle to the application of these. These issues led us to develop the Graphical Proteomics Data Explorer GProX , a software package for comprehensive and integrated bioinformatics analysis and visualization of large proteomics data sets.

The basic concept of GProX is to provide a data browsing environment similar to common spreadsheet applications and from this interface make available an array of functionalities for analyzing proteomics data. The major goal of GProX is thus to allow experimenters without specialized skills in bioinformatics to analyze their data and produce graphical representations to be used in scientific publications or presentations.

GProX focuses on making available a wide array of useful analysis functions within a single platform and focuses particularly on a user-friendly interface and the production of high-quality graphical objects. The overall structure and context of GProX is illustrated schematically in Fig.

The main program and the user interface are written in the Visual Basic programming language under the Microsoft. NET environment. The object-oriented architecture and the large selection of graphical objects available in the. NET environment allows creation of user-friendly graphical interfaces, which resemble common Microsoft Windows applications. Furthermore, the large repository of high-level functionalities implemented in.

NET makes it an efficient platform for interfacing data and communicating with the operation system OS. One drawback of the. But because most, if not all, mass spectrometer vendors proprietary software is only available for Windows, most proteomics labs anyway require Windows systems for data generation and analysis.

Overview of the GProX Structure. GProX accepts as input a tab- or character-delimited file containing as a minimum only protein accession keys and quantitative information. Initial analysis session setup is done via a simple input wizard, which also supports defining the experimental design. The user interface provides access to all functions and uses the R-environment for advanced analyses and generation of graphics. All files associated with an analysis session are saved locally and from the session file a stored session can be opened for continued analysis.

Most of the features in GProX for data processing and generation of graphical objects are implemented as scripts written for R, the free software environment for statistical computing and graphics 30 , see supplemental Fig. R has during recent years obtained increasing popularity for processing omics data, promoted especially by the rapidly growing number of add-in libraries available from the Bioconductor consortium In addition, R is well suited for processing the large amounts of numerical data produced by quantitative proteomics experiments and contains a range of well-developed functions for generating simple as well as advanced graphical outputs in a number of formats.

The interfacing between the. NET based user interface and R is achieved via tab-delimited files that are used as input for external R instances. After completion of the R-task, tab-delimited output files are interfaced back to the main program and graphical objects are saved locally and displayed in the main program.

During normal operation the user is not confronted with the R tasks, which are executed as external processes in the background. Not least for debugging purposes, both standard and error output from the R-process is fed back into the main program and saved locally.

These packages and their included functions can also be used directly or as a source of inspiration for experimenters familiar with R to modify or expand the functionalities currently implemented in GProX see supplemental Methods and supplemental Fig. NET environment installed. Since the program depends critically on a working installation of R and several add-in libraries, these components must also be installed on the user's computer.

During the first startup of GProX the user is prompted to download and install these components. To assist the user with this task we have included an automatic setup procedure. Also, detailed information about manual installation of R and add-in libraries is given in the GProX help.

Furthermore, the whole installation procedure is described in detail in the tutorial distributed along with the program. For further support we have created a GProX Help Google group where users can post questions and comments. The input format required by GProX is a tab- or character delimited file with column headers in the first row and each protein entry in separate rows.

The minimum information present for each protein in the input file is the database accession key s and quantitative information.

If needed, any additional information available from preceding data processing can also be imported from this input data file for subsequent applications within GProX. This additional information might be e. As a consequence of this generic input format the application of GProX is not restricted to a particular mass spectrometry instrumentation platform, quantitation technique or data processing and quantitation software.

Import of data into GProX is done via an input wizard see supplemental Fig. S2A in which the user is requested to select the input file, specify the columns containing accession keys and quantitation ratios and finally, if required, specify the experimental setup. To specify the experimental setup, data columns containing quantitative data can be allocated to separate experiments.

The arrangement of the experimental setup facilitates the analysis of more sophisticated quantitative proteomics experiments, where e. In this case, a single experiment would include quantitation data from different time-points for one treatment condition. Multiple independent experiments can then be analyzed either separately or together and compared within GProX. Upon creation of such a session, all information required to recreate a previous session is saved inside the session folder as a flat file.

GProX employs a data management setup in which the input data file is regarded as a database, from which only columns specified are placed in a session data table containing only relevant information for data analysis. Other data columns from the input table can be imported on demand during analysis and is appended to the session table s.

Because of the fact that all data processing is performed only on the active session table, the processing efficiency is improved and, in addition, the original input file is left unchanged. We have attempted to bring the graphics produced by GProX as close to a final state as possible, but users might want to fine-tune or layout their figures in an external graphics editor such as e. Adobe Illustrator or Corel Draw before using them for presentations or in publications.

To this end, several output formats, including vector eps, pdf and bitmap png, bmp, jpg, tif graphics enable the user to open and freely modify figures in external applications. The main user interface of GProX is similar in appearance to that of spreadsheet programs as e. Open Office Calc or Microsoft Excel. All operations within the program are accessible via a ribbon control, menus, and dedicated dialog boxes Fig. The main user environment is a multiple-document interface containing up to five windows supplemental Fig.

The Session Info window contains all information about the current session, including a list of all produced tabular and graphical objects as well as an overview of the specified experimental setup.

The Data Tables window contains the session tables as collection of tab-pages. Upon starting a new session, a single session table is created, but during the course of an analysis session the user can move subsets of this table to new session tables. Data analysis steps are performed only on the active tab-page, allowing the user to processes and analyze subsets of the complete data collection. GProX User Interface.

The multiple document user interface of GProX display, in dedicated windows, the data tables on which the analysis is performed, analysis results and all figures produced in the analysis session. All functions inside the program are accessible via a ribbon control see also supplemental Fig.

During the course of an analysis session a large collection of graphical objects can be created and these are displayed in a dedicated Graphics window. To navigate through the graphical objects the Graphics window contains an explorer panel to select displayable items and rename, delete, or move files. All tabular output from analysis steps is contained in the Analysis Tables window as tab page collection, similar to the Data Tables window.

Finally, the input table can be displayed inside GProX, this however, serves mainly reference purposes, because the input table is solely used as a database without changing its content. We have strived to make the software as intuitive and user-friendly as possible, but especially the more advanced analysis steps allow changing several associated parameters. To assist the user in selecting these parameters and to offer support in the basic use of the program, a compiled HTML help chm functionality and tooltip help boxes in individual dialogs assist in using the software.

Furthermore, a step-by-step tutorial describing an example workflow in GProX is distributed along with the program to help the users getting started with the program. Details about processing algorithms and data analysis strategies are described in the supplemental methods and outlined in supplemental Figs. S4 to S6. To demonstrate the features of GProX, a previously published quantitative proteomics data set comparing phospho-Tyrosine dependent signaling 5 and 30 min after epidermal growth factor EGF or hepatocyte growth factor HGF stimulation 33 was used the experimental setup is summarized in supplemental Fig.

To analyze these data sets, the data was imported to GProX specifying the IPI accession keys as protein identifiers and corresponding columns containing the quantitation ratios after EGF or HGF stimulation were allocated to two separate experiments.

An overview of the analysis steps outlined in the following sections is illustrated in Fig. A , Overview of the analysis steps performed to exemplify the application of GProX for analyzing quantitative proteomics data.

B , Plots of the ratios of one or more proteins and experiments can readily be requested to acquire a rapid overview of protein regulation. In this case, each panel includes regulation profiles from different experiments for individual proteins.

C , IPI- and UniProt database sheets can be readily requested for selected proteins to immediately provide the user with available information stored in these databases. Furthermore, these database entries link out to other primary resources or higher-level annotations.

One main goal of GProX is to provide a comfortable environment for browsing quantitative proteomics data in a spreadsheet-like fashion. Basic functions such as sort, find, deletion or insertion of rows and columns as well as arithmetic operations as e.

In this regard, data subsets can also be allocated to new data tables, providing data grouping based on e. Furthermore, the experimental setup defined during data import can be easily modified in the course of an analysis session, e. Quantitative data in the form of intensity ratios often requires transformation to other scales.